Crafting will not be as the normal MMORPG style, you don't make weapons in 40k, you learn how to use lost tech, so 'crafting' will be more of a discovering how to use artifacts to possess and less about actually crafting them, Im on my phone atm, but I'll add a link to an interview later.
Crafting only up to a certain point. You should be able to, if you have the right materials, add them to your Armour for a bit of extra protection or specialised bullets? But nothing that can give a big advantage like crafting an OP weapon is something I wouldn't really like to see crafting a stronger weapon than someone who hasn't crafted his is fine, but it shouldn't make too much of a difference.